Endothelial cell activation

Linking endothelial dysfunction with endothelial cell activation.

The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration. Endothelial dysfunction, as defined by a lack of NO, has been linked to a variety of disease states, including atherosclerosis, diabetes mel...

Endothelial cell activation, reduced endothelial cell reparative capacity, and impaired endothelial-dependent vasodilation after anger provocation.

Daichi Shimbo, MD1,*, Leah B. Rosenberg, MD2, William Chaplin, PhD3, Shuqing Zhao, MS1, Emma R. Goldensohn, BA1, Matthew Cholankeril, MD1, Jie Fu, MS1, Sang Been Hong, BA1, Sanja Jelic, MD1, and Matthew M. Burg, PhD1 1Department of Medicine, Columbia University Medical Center, New York, NY 2Department of Medicine, Duke University Medical Center, Durham, NC 3Department of Psychology, St. John’s ...

Microparticles Endothelial Cell Activation by Leukocyte

Endothelial cell activation by leukocyte microparticles.

The ability of polymorphonuclear leukocytes (PMNs) to modulate endothelial cell (EC) activation was investigated. Adding PMNs to cultured HUVECs resulted in a release of IL-6 (888 +/- 71 pg/ml, a 35-fold increase over release by the two cell types alone) and IL-8 (45.2 +/- 14.5 ng/ml, a 6.4-fold over PMN release alone and a 173-fold increase over EC release alone). In contrast, the release of T...

CD39 modulates endothelial cell activation and apoptosis.

BACKGROUND CD39 is the dominant vascular nucleoside triphosphate diphosphohydrolase (NTPDase) that exerts major effects on platelet reactivity by the regulated hydrolysis of extracellular adenine nucleotides. The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored. MATERIAL AND METHODS Recombinant replication-deficient adenoviruses were constructed with hum...